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Research Areas: Electrocatalysis, Applied Electrochemistry, Sensors and Biosensors Brief Description of Research: In addition to it Dr. Atanassov has significant industrial and professional R&D experience in applied electrochemistry and particularly in the development of electrocatalysts for electrochemical power sources, engineering of batteries and fuel cells, materials research and materials engineering. His research program in applied electrochemistry focuses on new electro-catalysts discovery, biomimetic approaches in electrocatalysis and bio-fuel cells research. Current research projects include development of non-platinum catalysts for Proton Exchange Membrane Fuel Cell and Direct Methanol Fuel Cells and electrocatalytic gas sensors, including NOx and O2 sensors. Current research interests in biosensing include systems based on bio-electrocatalysis. Fundamental studies in bio-electrocatalysis are focused on investigation of direct electron transfer enzyme catalyzed red-ox reactions. Research on electron exchange between enzyme active site and a metal/carbon electrode and role of protein globule in electrocatalysis, conformational and electrostatic interactions, intramolecular electron transfer through the polypeptide chain, role of functional groups and metal ions on the electron transfer constitute the basic science effort. Fundamental engineering studies are focused on catalytic aspects of direct electron transfer, catalytic elimination of overvoltage, and achieving equilibrium potentials at technically realistic times, etc. The applications of these basic studies are being sought in engineering of biosensors based on electrochemical detection of direct electron transfer, enzyme sensor for direct detection of substrates of enzymes expressing bio-electrocatlytic properties and enzyme-labeled immunoassay of DNA sensors with direct electron transfer detection of enzyme labels; development of the assay format and system engineering of biosensor devices. |
Among the biosensor engineering projects the GeneSensors: enzyme labeled DNA/RNA assay is being currently pursued with an aim to design a disposable flow-through analysis with in-situ and/or down-stream detection of DNA hybridization.
Representative Publications:D. Ivnitski, I. Abdel-Hamid, P. Atanasov, E. Wilkins and S. Stricker, Application of Electrochemical Biosensors for Detection of Food Pathogenic Bacteria, Electroanalysis, 12 (2000) 317-325.
D. Ivnitski, I. Abdel-Hamid, P. Atanasov, and E. Wilkins, Biosensors for Detection of Pathogenic Bacteria, Biosensors & Bioelectronics, 14 (1999) 599-624
A.L. Ghindilis, P. Atanasov, M. Wilkins and E. Wilkins, Immunosensors: Electrochemical Sensing and Other Engineering Approaches, Biosensors & Bioelectronics, 13 (1998) 113-131
A.L. Ghindilis, P. Atanasov and E. Wilkins, Enzyme Catalyzed Direct Electron Transfer: Fundamentals and Analytical Applications, Electroanalysis, 9 (1997) 661-674
P. Atanasov and E. Wilkins, In Vivo Rechargeable Glucose Biosensors. (An Overview), Sensors & Actuators - B, 35-36 (1996) 435-447
E. Wilkins and P. Atanasov, Glucose Monitoring: State of the Art and Future Possibilities. Medical Engineering & Physics, 18 (1996) 273-288