Centennial Engineering Center - Room 2057
- Ph.D. University of Colorado, Chemical Engineering , 2004
University of Colorado, Chemical
Engineering , 2001
- B.S. University of California, Berkeley, Chemical Engineering with Biotecnology Emphasis, 1999
University of California, Berkeley, Chemistry, 1999
The research in my group focuses on understanding the structure, dynamics, and stability of proteins. Currently, there are three research areas in my group: 1. mechanism of protein misfolding and aggregation in the pathogenesis of neurodegenerative diseases, such as Alzheimers disease and Parkinson's disease, 2. dynamics of proteins at interfaces, both artificial and physiological interfaces, and 3. stabilization of proteins for bioengineering applications, including biopharmaceuticals, biosensors, and biofuel cells. We use a wide range of biophysical tools in our research, including static and dynamic light scattering, numerous spectroscopic methods, chromatography, surface characterization techniques, and X-ray and neutron scattering. We apply the fundamentals in thermodynamics, kinetics, transport, and intermolecular and surface interactions to study our systems.
- 2008 - Present: Assistant Professor, Department of Chemical & Nuclear Engineering and Center for Biomedical Engineering University of New Mexico, Albuquerque, NM
- 08: Postdoctoral Research Fellow, Department of Chemistry, Institiure
for Biophysical Dynamics and the James Franck Institute The
University of Chicago, Chicago, IL
Research Project:Cell membrane-mediated amyloid-ß fibrillogenesis and neurotoxicity
- ChNE 101 Introduction to ChNE Fall 2008/Spring 2009.
- ChNE 542 Advanced ChE Thermodynamics Fall 2008.
321 Mass Transfer Spring 2009.
Ongoing Research Support:
Association New Investigator Research Grant, 07/01/2009 - 06/30/2011
Lipid membrane mediated tau aggregation and toxicity
Ridge Associated Universities Ralph E. Powe Junior Faculty Enhancement
Lipid membrane-templated protein misfolding in Alzheimer's disease
of New Mexico Research Allocation Committee, 01/01/09-12/31/09
Interaction of tau protein with lipid membrane in the pathogenesis of Alzheimer's disease
Force Research Laboratory, 09/15/2008-09/14/2009
Bio/nano architectures for enzyme catalyzed energy conversion
of Naval Research, 10/01/2009-09/30/2010
A Comprehensive Facility for Surface Plasmon Resonance Spectroscopy at the University of New Mexico
- L Ding, EY Chi, S Chemburu, E Ji, KS. Schanze, GP Lopez, DG Whitten, Insight into the mechanism of antimicrobial poly(phenylene ethynylene) polyelectrolytes: interactions with phosphatidylglycerol lipid membranes, (2009) Langmuir, Article ASAP
- MK Ratajczak, EY Chi, SL Frey, KD Cao, LM Luther, K Kjaer, J Majewski, KYC Lee, Ordered nanoclusters in lipid-cholesterol membranes, (2009) Physical Review Letters, 103, 028103
- PC Stenger, G Wu, CE Miller, EY Chi, SL Frey, KYC. Lee, J Majewski, K Kjaer, JA Zasadzinski, X-Ray diffraction and reflectivity study of the competitive adsorption of lung surfactant and albumin, (2009) Biophysical Journal, in print
- SL Frey, EY Chi, Arratia C, KYC Lee. Condensing and fluidizing effects of Ganglioside GM1 on phospholipid films, (2008) Biophysical Journal, 94: 3047-3064.
Chi, C Ege, A Winans, J Majewski, G Wu, K Kjaer, KYC Lee. Lipid
membrane templates the ordering and induces the fibrillogenesis of
Alzheimer's disease amyloid-beta peptide, (2008) Proteins, 72: 1-24.
- EY Chi, SL Frey, KYC Lee. Ganglioside GM1-mediated amyloid-beta fibrillogenesis and membrane disruption, (2007) Biochemistry, 46: 1913-24.
- EY Chi, BS Kendrick, JF Carpenter, TW Randolph. Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist, (2005) Journal of Pharmaceutical Sciences, 94: 2735-2748.
- EY Chi, J Weickmann, JF Carpenter, MC Manning, TW Randolph. Heterogeneous nucleation controlled intermittent aggregation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation, (2005) Journal of Pharmaceutical Sciences, 94: 256-274.
- EY Chi, S Krishnan, TW Randolph, JF Carpenter. Physical stability of proteins in aqueous solution: mechanism and driving forces in non-native protein aggregation, (2003) Pharmaceutical Research, 20, 1325-133.
Total Publications in Career:
Publications, 30+ Invited Talks, Presentations and Posters